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Familial binary data are the dichotomous responses along with covariates collected from family members. The dependence among the members is very important in modeling this type of data. In this presentation, hierarchical Archimedian copula models are proposed to model the data with the dependence taken into consideration, and various hierarchy strategies are also compared using a real life example

This article describes the self-publishing journey, challenges and methods of development, impact, the value of a self-published e-textbook in tenure decisions, and recommendations. This journey led to the self-publishing of an e-textbook for iPad® delivery at a Midwest university for a course on electronic distribution and hotel management in the Consumer and Family Sciences curriculum. Factors leading to this decision included the context of the digital hospitality world, industry standards, technology use by students, lack of interest by major publishers, e-textbook and iPad learning research, and iPad technical and training support available to a cohort of faculty on campus

Vitiligo is an autoimmune disease in which depigmented skin results from the destruction of melanocytes, with epidemiological association with other autoimmune diseases. In previous linkage and genome-wide association studies (GWAS1 and GWAS2), we identified 27 vitiligo susceptibility loci in patients of European ancestry. We carried out a third GWAS (GWAS3) in European-ancestry subjects, with augmented GWAS1 and GWAS2 controls, genome-wide imputation, and meta-analysis of all three GWAS, followed by an independent replication. The combined analyses, with 4,680 cases and 39,586 controls, identified 23 new significantly associated loci and 7 suggestive loci. Most encode immune and apoptotic regulators, with some also associated with other autoimmune diseases, as well as several melanocyte regulators. Bioinformatic analyses indicate a predominance of causal regulatory variation, some of which corresponds to expression quantitative trait loci (eQTLs) at these loci. Together, the identified genes provide a framework for the genetic architecture and pathobiology of vitiligo, highlight relationships with other autoimmune diseases and melanoma, and offer potential targets for treatment

Individuals in pursuit of, or currently in, a romantic relationship typically communicate via technology, extending to sexting with one another. Sexting is commonly understood as the sending and receiving of sexually suggestive or sexually explicit photos, video, or text via cell phone or other technologies. The characteristics that fuel whether one engages in sexting are not well understood. In this study, 459 unmarried, heterosexual undergraduate students (female = 328; male = 131), aged 18 to 25 years, from three universities completed an online questionnaire about their behaviors with technology and romantic relationships. In general, low attachment avoidance and high fear of negative evaluation from the dating partner predicted sending a sexually suggestive photo or video, sending a photo or video in one’s underwear or lingerie, and sending a sexually suggestive text. High fear of negative evaluation predicted sending a nude photo or video as well as sending a text message propositioning sex. Low attachment avoidance, greater fear of negative evaluation, and greater social distress when dating were associated with sexting behaviors

The controversial Rahn Curve is the relation of government spending with economic growth. It is argued that government spending is inefficient and should therefore be negatively related or uncorrelated with the growth of Gross Domestic Product (GDP). Whether there is a Rahn Curve is an empirical question which has been examined with mixed results for the U.S. economy. There has been little effort to disaggregate federal expenditures to see if there are components which are highly correlated with economic growth. However, some components of government spending which are theoretically related to economic growth, e.g., social security, funding of research grants, infrastructure building, and education. On the other hand, other expenditures such as debt service, police protection, even military spending does much to aid GDP growth. This paper uses components of federal expenditures as the explanatory variable for GDP growth

From the beginning, a code of ethics for bioethicists has been conceived of as part of a movement to professionalise the field. In advocating for such a code, Baker repeatedly identifies u27having a code of ethicsu27 with u27professionalizationu27. The American Society of Bioethics and Humanities (ASBH) echoes this view in their code of ethics for healthcare ethics consultants (HCECs)1 and the subsequent publication in the American Journal of Bioethics.2 Taking for granted that a code of ethics could be a valuable asset for HCECs, this essay has two aims. First, there are good reasons to doubt that the label u27professionu27 has significant meaning for HCECs. Attempts to accurately conceive of a profession fall into two broad camps: substantive and formal. Substantive conceptions should be rejected. Specifically, substantive conceptions beg the question about what it means to be a profession, which produces devastating problems for practical application. Formal conceptions of profession (eg, Davisu27 conception3) avoid begging the question, but do so at the cost of identifying the responsibilities of a profession. Using the term u27professional responsibilitiesu27, then, requires additional explication and classifying HCECs as professionals requires the identification of their role-specific responsibilities.i Second, this essay will critique the ASBH code of ethics for HCECs as a first articulation of these responsibilities. As written, this code of ethics has limited value for HCECs because most of the responsibilities identified in this code do not identify HCEC-specific responsibilities. In closing, some important strategies to improve upon this initial attempt to define the responsibilities of HCECs are identified

Essays on Aesthetic Genesis is a collection of essays written on Jeff Mitscherling’s work in realist phenomenology, Aesthetic Genesis: The Origin of Consciousness in the Intentional Being of Nature. The authors explicate, expand, contextualize and apply the concepts of intentional being, the “New Copernican Hypothesis” (a reversal of the fundamental tenet of phenomenology that all consciousness is intentional—intentionality, rather, gives rise to consciousness), the idea of intentional structures in nature, and the foundational concepts of Aesthetic Genesis as they appear in the work of Aristotle, Ingarden and Gadamer amongst others. This book takes as its focus Mitscherling’s comprehensive phenomenological analysis of embodiment, aesthetic experience, the interpretation of texts, moral behavior, and cognition, and exemplifies subsequent work in the field of realist phenomenology being conducted by an international collection of active scholars influenced by Aesthetic Genesis

Join that sweet transvestite and his motley crew and do the Time Warp! Richard Ou27Brienu27s campy West End musical led to the cult classic film famous for midnight showings. Fans may remember Ou27Brien best as Riff Raff on the big screen.A humorous tribute to the science fiction and u22Bu22 horror films, this musical tells the story of a newly engaged couple getting caught in a storm and coming to the home of a mad transvestite scientist. Dr. Frank N. Furter unveils his new creation, an artificially made, physically perfect muscle man named Rocky Horror.Just like the film, this show is all about audience participation. Join the fun with cascading toilet paper, other props, sassy retorts and dancing the Time Warp! When you experience it LIVE...this deliberately kitschy rock u27nu27 roll sci-fi gothic is more fun than ever

Eclectica is an ensemble featuring string instruments that speak quietly in a noisy world! Eclectica performs a wide and diverse repertoire of music from the past (Baroque, Renaissance, folk) and the present (jazz, contemporary, classical) and includes performers Robert Margo, Elizabeth Piercy, Anne Martin, Russell Bookout and Melanie Bookout

The giant panda is an icon of conservation and survived a large-scale bamboo die off in the 1980s in China. Captive breeding programs have produced a large population in zoos and efforts continue to reintroduce those animals into the wild. However, we lack sufficient knowledge of their physiological ecology to determine requirements for survival now and in the face of climate change. We measured resting and active metabolic rates of giant pandas in order to determine if current bamboo resources were sufficient for adding additional animals to populations in natural reserves. Resting metabolicrates were somewhat below average for a panda sized mammal and active metabolic rates were in the normal range. Pandas do not have exceptionally low metabolic rates. Nevertheless, there is enough bamboo in natural reserves to support both natural populations and large numbers of reintroduced pandas. Bamboo will not be the limiting factor in successful reintroduction

This paper presents a pragmatic way of introducing pre-service teachers to multiple literacies and critical literacy through childrenu27s-literature-based engagements. The concepts of multiple literacies and critical literacy are reviewed, and their interrelationship is explained. Two instructional engagements, which connect theory to practice through childrenu27s books, are then discussed in detail. This paper argues that the instruction of multiple literacies and critical literacy is aligned with the definition of literacy as multiple social practices, which should be examined critically. In addition, the utilization of childrenu27s books provides a feasible way to help such instruction take root in the classroom